Sentence examples for molecular defects are from inspiring English sources
The molecular defects are heterogeneous but most of the cases are associated with defective DNA methylation at either one of two Imprinting Control Regions (IC1 and IC2) or Uniparental paternal Disomy (UPD) at 11p15.5.
Thus molecular defects are visible from late second instar and increase into third instar stage, note however that even at mid-to-late third instar stage little tissue degeneration is observed (unpublished and see [7].
Heterogeneous molecular defects are present at 11p15.5 in the individuals affected by BWS (1).
In AD-affected neurons, abnormalities in these cellular pathways are readily observed already at early stages of disease development, and even though many studies agree that defective lysosomal degradation may relate to or even underlie some of these deficits, specific upstream molecular defects are still deliberated.
Despite considerable functional redundancy amongst TGFβ superfamily members in the developing kidney [11], morphological and molecular defects were detected in betaglycan+/− and betaglycan−/− kidneys.
A stratified and targeted approach based on the underlying molecular defects is evolving.
The neuromuscular junction defects were described in a large number of cases, in most of whom the molecular defects were eventually identified many years later.
To ascertain whether molecular defects were present in normal intestinal tissue in young Fbxw7 mutant mice, we examined a range of cell lineage markers.
Similarly, data on tumor risk for specific molecular defects is too limited to be clinically useful at this time, although the studies noted above have reported high tumor risk with methylation of H19 with or without UPD.
Future studies will further explore the structural implications of the functional results herein presented, and define whether such specific molecular defect is associated with distinct clinical features.
The abnormal protein was identified in the 1940s, the precise molecular defect was identified in the 1950s, and the three-dimensional structure of the protein was defined in the 1960s.
