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So, for example, a new drug for a type of lung cancer attacks a molecular defect that is also found in neuroblastoma – a devastating and often lethal children's cancer – but it will not be put through trials to make it available to children.
To define the molecular defect that causes analbuminemia in an apparently healthy boy, son of non-consanguineous Swiss parents.
Here we report the first case of hereditary analbuminemia in the ethnic Swedish population, and we define the molecular defect that causes the analbuminemic trait.
Here we report three new cases of hereditary analbuminemia, fortuitously detected in three Slovak Romany children, members of the same family, and define the molecular defect that causes the analbuminemic trait.
This result suggests that the molecular defect that causes the Mrt phenotype in the hrde- 1 mutant is transgenerationally cumulative and reversible.
In addition, a system of nosology was introduced that grouped the FTLD subtypes into broad categories, based on the molecular defect that is most characteristic, according to current evidence.
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Proteomics (the study of protein profiles associated with the genome), patterns of gene activity, and genomics (the study of the genome itself) can be used to identify molecular tumour signatures and thereby enable tumours to be classified on the basis of the molecular defects that cause them.
They can't reveal the molecular defects that indicate whether an abnormal lump is cancerous or benign.
SU-11248 is one of a new spate of cancer pills that work by targeting several of the molecular defects that cause the disease at one time.
The ability to methodically analyze the expression patterns of thousands of genes simultaneously allows for identification of groups of molecular defects that lead to chronic inhibition of the wound-healing process.
Further studies are necessary to elucidate fundamental molecular defects that lead to CIMP-high colorectal cancer.
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