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Usually, these two key types of molecular data sources are not integrated in a combined analysis [ 6].
The resulting model is as consistent as possible with the pertaining tissue-specific molecular data sources [ 6, 13].
Prior to the molecular revolution, phylogenetic data were comparatively limited, with only morphology being generally available (ignoring early molecular data sources such as DNA-DNA hybridization or immunogenetic and serological data).
In order to ease the integration process, a first level of views on the molecular data sources was created to aggregate information regarding their main concepts like gene, QTL or marker.
ML entities correspond to clades labelled in Figure 2. The use of multiple molecular data sources enables the comparison of the evolutionary history of each gene and potentially more accurate estimation of the evolutionary history of the focal organisms (e.g. [ 58]).
The human metabolic model was generated based on MBA algorithm [ 8], which is a model-building algorithm used to derive tissue-specific metabolic models from a generic model [ 6] by integrating a variety of tissue-specific molecular data sources, including literature-based knowledge, transcriptomic, proteomic, metabolomic and phenotypic data.
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Based on the clustering of cases in space and time and molecular data, common-source acquisition of this unusual drug-resistant species is possible.
Anyone seeking to repeat Watson and Crick's model building would certainly have to acquire additional molecular data from another sources.
Of these patients, 106 patients were assigned an ELN risk group based on complete cytogenetic and molecular data extracted from source documents.
Molecular data from several independent sources have therefore been sought in pursuit of resolving these deep splits.
Databases with integrative analyses These databases provide results representing analysis of data across a cohort of samples where statistical methodologies and computational algorithms were applied to identify molecular subtypes from various data sources [ 38 ].
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