The observations summarized above are difficult to reconcile with molecular data previously published on this putative generalist species (e.g. Morris and Mound 2004; Hoddle et al. 2008).
Indeed, molecular data previously generated showed that EAAT1 and EAAT2 mRNA levels are largely modified in ALS patients and, moreover, these modifications were associated with the increased oxidative stress present in the affected cases (24, 25).
Images were scored independently by four reviewers blind to the molecular data as previously described [ 46].
In this collaborative case series, we present clinical and molecular data for 14 previously unreported individuals from 11 unrelated families who harbor compound heterozygous or homozygous TANGO2 variants, expanding the molecular profile and clinical phenotype of TANGO2-related disorder.
This is the result of a couple of factors, including increased interest in taxonomy, changes in species concepts that favored the recognition of more species, and DNA and other molecular data that showed previously unrecognized diversity.
Although no single method worked flawlessly in recognising species, molecular data have largely supported previously inferred relationships that were based on the other characters [ 3].
In order to compare our molecular data with Plasmodium species previously found in lemurs, we included a species isolated from E. m. macaco identified at the Muséum National d'Histoire Naturelle, Paris, France [ 23].
Molecular evidence [ 2, 5] has suggested that Nycteridae is not a member of that clade, but a sister group to Emballonuridae, whereas molecular data have brought two previously unassociated groups, Rhinopomatidae and Craseonycteridae, traditionally arranged together with Emballonuridae in the superfamily Emballonuroidea, into the Rhinolophoidea.
An examination of the data available for lowland tapirs contained within the above period highlights an unexplained gap between previously published molecular data and fossil evidences.
As minimization of inbreeding is probably as important a determinant as rehabilitation of habitat for long-term survival of the repatriated population [ 5- 8], we previously used molecular data to assess how much of the genetic diversity of the 15 breeders is represented in the repatriated population [ 9].
The lemuriform primates of Madagascar have undergone a recent explosion in species descriptions, with as many as 47 new species described in the last 25 years as a result of intensified field work, the incorporation of molecular data in the identification of previously cryptic species, and a paradigm shift in what we recognize as a species [ 10- 12].
