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The phylogenetic relationships within the Oribatida are unclear, some studies solely based on molecular data addressed the phylogeography and/or phylogeny of selected taxa only [ 19, 27- 30] and very little emphasis has been put on characterizing the evolution of particular traits in a phylogenetic framework.
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Using these molecular data, we addressed to clarify 1) frequency and timing of the gene rearrangements, 2) phylogenetic relationships among major acrodont groups, and 3) historical biogeography of acrodont lizards in their higher taxonomic level.
(4) Incomplete outcome data addressed?
In the United States, the exchange of molecular data has been addressed by the establishment of PulseNet, a national molecular typing scheme based on a standard method for PFGE; a similar network is being set up for the major Salmonella reference laboratories in Europe with research funding from the European Commission.
There are data addressing the molecular mutation rate.
A significant limitation of the manuscript, as was discussed by the three reviewers, is the lack of experimental data addressing the molecular mechanisms underlying the authors' observations.
Molecular data used to address this major evolutionary question have so far been limited to a handful of markers and/or taxa.
Molecular data provide invaluable information to address many ecological and evolutionary questions.
However, studies addressing this problem in molecular data are scarce because detection of the trap is not straightforward.
Specifically, we address the following questions: (1) Do molecular data support the morphology-based field identification of Bruguiera × rhynchopetala?
Systems biology and network approaches address to the problem of complexity by integrating molecular data at multiple levels of biology including genomes, transcriptomes, metabolomes, proteomes and functional and regulatory networks (Kohl et al., 2010).
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