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One theory is that there may be a trade-off in the body between growth and repairing molecular damage in cells.
Together these data showed that there was a statistically significant and consistent increase in ROS production and associated molecular damage in ageing C. elegans.
Each recovered sequence showed some signs of molecular damage in the form of DNA fragmentation and type 2 miscoding lesions to a lesser extent, indicating authentic ancient DNA.
This study provides evidence for similarities in cartilage molecular damage in osteoarthritic (OA) joints.
In other words, by lowering robustness "accumulation of molecular damage" in the brain would precipitate stroke.
As commonly depicted [ 3], aging (loss of homeostasis), caused by molecular damage, in turn causes death via two independent ways (Fig. 4A).
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Cellular defense mechanisms are able to avoid molecular damages in a wide range of environmental conditions.
On the other hand, yes, molecular damage is involved in something like cancer that can limit lifespan in mammals to some extend.
Not only levels of molecular damage are low in normal cells, but also there is no amplification and selection.
Most models have one common theme: the accumulation of molecular damage that results in a subsequent deterioration of cellular and tissue structure and function.
But in general molecular damage is a key factor in cancer origin.
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