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Based on this approach, we propose now to define a molecular criterion, able to discriminate the ability of linear polymers to give rise to sharkskin in extrusion.
Such an effort could be limited to a subset of tumors undergoing a specific treatment: any molecular criterion that predicts outcome of a subgroup of glioma to a specific treatment would be a major leap forward.
An essential molecular criterion defined from the observation of PrPres BSE compared with scrapie was the low molecular mass of the unglycosylated band in PrPres BSE, associated with a decreased PrPres signal lower with an N terminal antibody than with a core antibody (13, 22, 36 ).
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However, the molecular criteria rely on discerning subtle differences in TP53 (bi-allelic vs. deletion) and 1q (amp vs. gain), so it is important that diagnostic tests can easily discriminate between them.
Recent advances in genomics and epigenomics have ushered in an era of defining cancers based on molecular criteria.
Molecular tools compatible with the analysis of very small amounts of material have resulted in research aimed at designing molecular criteria to define this competence.
A next-generation diagnostic tool for bacterial vaginosis, consisting of quantitative and/or qualitative molecular criteria, has not yet been identified.
Nonetheless, lymphomas triggered by suppression of Amd1 or Eif5a arise independently of p53 loss, because shRNAs targeting each gene alone were sufficient to trigger lymphomas with aggressive features (Fig. 2e, f) and those lymphomas expressing Eif5a shRNAs retained intact p53 function as assessed by several functional and molecular criteria (Supplementary Figs 8 and 9).
We have now designed four mutants of vimentin coil 1A, modifying key a and d positions in the heptad repeat pattern, with the aim of investigating the molecular criteria that are needed to stabilize a dimeric coiled-coil structure.
The sum of both character states of morphological and molecular criteria (326 attributes & 353 bands) respectively of total (679 attributes) of the investigated taxa were subjected to a numerical analysis using NTsys-pc program (version 2.02).
Based on genetic and molecular criteria, the proteins that govern PCP can be divided into distinct modules, including the core module, the Fat/Dachsous/Four-jointed (Fat/Ds/Fj) module (often referred to as the 'global' module) as well as tissue specific effector modules.
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