Sentence examples for molecular context that from inspiring English sources
He also discovered how cells communicate the molecular context that enables each cell to function appropriately.
To exploit these alterations, it is necessary to understand how they define a molecular context that allows increased sensitivity to particular compounds.
Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.
The other NOTCH1 pathway genes targeted by frequent copy number gains illuminate a molecular context that may constrain NOTCH signaling towards biological effects relevant for PGL tumorigenesis.
Consequently, studies focusing on one or a few genes are likely to miss the molecular context that could be vital for a comprehensive understanding of the disease.
We concluded that during the transformation process, SV40EReg provides a cellular and molecular context that synergizes with the senescent secretory profile to promote sensitization toward TRAIL.
There are few experiments regarding the effects of chronic, low-dose alterations and even fewer studies that consider the different cellular and molecular contexts that can arise over the course of a lifetime.
To explain such differences, it has been proposed that both EGF and NGF stimulation induce a specific 'molecular context' that determines the topology of the signal transduction network (Santos et al., 2007).
This may be due in part to a molecular intracellular context that sustains self-renewal and/or high proliferative potential.
Alternatively, it is possible that the minimum 'threshold' of mechanical forces varies depending upon location in the embryonic limb, meaning that some parts of the developing limb are more sensitive to mechanical stimulation than others due to the molecular context in that region.
At the coarsest level, a rule indicates that a reaction center can undergo a reaction regardless of the molecular context in which that reaction center is found, and a single rule defines a set of reactions, one for each unique context in which the transformation of the rule can take place.
