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One of Schaffner's replies to Hull regarding the one-many objection is that the molecular context of a mechanism can be included in the premises to the extent that it matters.
This atom characterization approach allows a description of the molecular context of an atom (environment) without having to include the next layer of atoms as pseudo atoms as in other approaches [76].
In addition, recent reports show that gene copy number adds a further level of complexity in understanding the molecular context of health and disease states.
Not only does this illustrate that physical and coexpression maps capture different dimensions of biological function, but it also illustrates the necessity of using both maps to provide complementary information in evaluating the molecular context of network hypotheses.
We applied network analysis methods to elucidate the molecular context of differentially expressed signaling molecules (network clusters) and to reconstruct pathways between transcription factors and upstream regulators of their activity (key nodes).
Molecular context of these proteins interaction was next explored with STRING database.
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This model provides a simple molecular context for understanding several features of IR/IGF1R activation and suggests directions for future study.
Although these discrepancies demonstrate that the molecular context outside of the immediate cleavage site can modulate sensitivity to cleavage by caspase-2, this study's transcriptional reporter assays proved useful in identifying sequences that were confirmed to be sensitive to caspase-2 proteolysis in other molecular environments.
Recent data, however, have identified a role for miRNAs from this family as tumor suppressors (O'Donnell et al., 2005), highlighting the importance of cellular and molecular context in determining the role of specific miRNAs in tumorigenesis.
While our observations reflect consistent behavior seen in the database, we cannot claim that they are completely general because of the narrowness of the molecular context.
However, a systematic protein expression analysis in all histological areas of CRC, the examination of RKIP expression in tumour buds and the systematic investigation of the molecular pathology context of RKIP expression was not performed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com