The higher level situation that is determined by the molecular constellation then can be logically derived from this specification the higher level situation that is determined by the molecular constellation.
One may speculate that the strong association of MGMT hypermethylation with 1p/19q codeletion [ 9, 88, 124] and IDH1 mutation [ 108] (Fig. 3) may reflect a global molecular constellation in anaplastic gliomas that per se is associated with higher sensitivity to cytotoxic therapy and more favorable outcome.
AO is distinguished from other brain tumors by a unique constellation of molecular genetic alterations, including the coincident loss of chromosomal arms 1p and 19q in 50 70% of tumors (Gregory et al. 1998).
Roseta-NBv5 © Juan Ignacio Jimenez (Spain) Measuring 50 light years in diameter, the large, round Rosette Nebula is found on the edge of a molecular cloud in the constellation of Monoceros the Unicorn.
Anaplastic oligodendrogliomas further share a constellation of molecular genetic alterations including coincident loss of chromosomal arms 1p and 19q in 50 70% of tumors [ 5].
In this setting, AOs are also distinguished by a unique constellation of molecular genetic alterations that can distinguish OD from astrocytomas and other glioma subtypes.
If, however, these protein abnormalities are not associated with LM deficits, an alternate explanation is that one or more trisomic proteins directly or indirectly act to protect the Dp10 from the deleterious effects of overexpression of other trisomic genes, i.e., the constellation of molecular abnormalities seen here is a sum of deleterious effects and neutralizing, compensatory responses.
The Orion Molecular Cloud Complex extends throughout the constellation of Orion and includes Barnard's Loop, the Horsehead Nebula, M43, M78, and the Flame Nebula.
The constellation also contains the conspicuous molecular cloud called the Coalsack.
In the north of the constellation is the Corona Australis Molecular Cloud, a dark molecular cloud with many embedded reflection nebulae, including NGC 6729, NGC 6726 7, and IC 4812.
