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Because the molecular connectivity between polymer and inorganic components facilitates the realization of very high concentrations of inorganic component, particle brush-based composites hold the promise to realize novel high-performance engineering materials with a wide range of applications, for example, in the area of energy storage or optical materials.
Indeed, by taking into account molecular connectivity between viruses and diseases, the Human Infectome-Diseasome Network generates new mechanistic hypothesis concerning their molecular relationships.
Protein-protein interaction maps also indicate a high level of molecular connectivity between different biological pathways thus highlighting the inter-related functions of many biological processes [ 8].
In this study, we aimed to identify the important proteins and the biological regulatory pathways involving in EH and further explore the molecular connectivity between these pathways by the topological analysis of the PPIs network derived from the proteins encoded by casual or susceptible genes for EH.
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In this study, we aimed to identify the key proteins and the biological regulatory pathways involving in EH and further to explore the molecular connectivities between these pathways by the topological analysis of the Protein-protein interaction (PPI) network.
Molecular connectivity maps between drugs and genes/proteins in a disease-specific context can be particularly valuable because they allow researchers to evaluate drugs against each other using their unique gene/protein-drug association profiles.
Molecular connectivity maps between drugs and genes/proteins in specific disease contexts can be particularly valuable, since the functional approach with these maps helps researchers gain global perspectives on both the therapeutic profiles and toxicological profiles of candidate drugs.
For both compounds, poor or no correlations were established between log Kd and acid dissociation constant (pKa1), and between log Kd and a variety of molecular connectivity indexes.
The concept of molecular connectivity maps has been proposed to establish comprehensive knowledge links between molecules of interest in a given biological context.
In post-genome biology, molecular connectivity maps have been proposed to establish comprehensive knowledge links between molecules of interest in a given biological context [ 14].
Systems biological approach of molecular connectivity map has reached to a great interest to understand the gene functional similarities between the diseases.
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