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Pharmaceutical scientists need to first identify the proteins that cause a disease and then find molecular compounds that can bind to those proteins.
The discovery of small molecular compounds that expand cartilage is needed.
We searched for small molecular compounds that expand cartilage or enhance the actions of bone morphogenetic proteins (BMPs) on cartilage.
There are at least three explanations for the association between adiposity and higher serum levels of molecular compounds that regulate inflammation and thrombosis.
Enzymatic products were then separated by two-dimensional TLC (2D-TLC) by sequential use of two customized mobile phases in order to discriminate molecular compounds that may differ for a single atom of hydrogen.
With this atomic structure as a basis, we are able to screen for small molecular compounds that bind to amyloid fibers, stabilizing them and possibly reducing amyloid toxicity.
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Take those ribosomes and give them a mixture of sugars, amino acids, adenosine triphosphate (the molecular compound that breaks down to provide energy for all biological functions) and new DNA with a different set of instructions on what to make and voila!
Plate B was necessary because the goal of this study was to identify small molecular compound that can reverse drug resistance and not to determine cell toxicity.
Small molecular compound that were associated with cell survival in plate A and plate B and death in plate C were identified as "hits" and selected for further study.
A metabolite is a molecular compound that is a reactant or product in an enzyme reaction.
The NSC23925 (2- 4-methoxyphenyl -4-quinolinyl) (2- 4-methoxyphenyl -4-quinolinylmall molecular compound that was identified as an effective and selective inhibitor of Pgp in previous studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com