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Although their underlying mechanisms have been extensively analyzed, only a fraction of the potential molecular components have been identified.
It has long been known that a complex, glycoprotein-rich extracellular matrix layer surrounds the developing optic cup throughout the process, yet the functions of the matrix and its specific molecular components have remained unclear.
The molecular components have just started to become apparent, and we add another layer of regulators, namely miRNAs.
Evidence for the existence of two endocytic modes has been obtained in pollen tubes [ 29, 43] and all the required molecular components have been identified [e.g. [ 9, 34, 44]].
Over the years, the general organization of membrane transport along the secretory pathway has been gradually unraveled (Mellman and Simons, 1992; Mellman and Warren, 2000), and many of the underlying molecular components have been identified (Rothman, 2002; Schekman, 2002; Emr et al., 2009).
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But the goal of achieving a flexible toolbox of reusable molecular components has been shown to be limited due to circuit unpredictability, incompatible parts or random fluctuations.
Each of these molecular components has orthologous elements in mice, although the mammalian system also differs in some key respects.
Identification of the multiple mechanisms responsible for the production of pain syndromes and their molecular components has been a major advance in our understanding of pain 18.
The surface density of these fusion-competent FPs is considerably smaller than the surface density of SNAREs because it is restrained by that molecular component having the lowest concentration.
This is complicated by the fact that some pathways assume a particular molecular component has a constant value whereas that component has production or removal within a parallel pathway.
However, the positions and orientations of the molecular protein components have changed by up to 9.7 Å and 11.7°, respectively (Table 8), which is far greater than the RMS Cα atom differences between quasi equivalent positions of the component molecular components in the CHIK VLPs (maximum RMS distance is 2.4 Å, Table 4).
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