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Indeed, considered as the 'holy grail' of synthesis in the late 1980s and early 1990s, this extraordinary molecule stands as the quintessential symbol of all natural product molecular complexity, and its total synthesis as the single most important milestone of complex molecular construction in recent decades.
Zamir, E. & Geiger, B. Molecular complexity and dynamics of cell-matrix adhesions.
Zamir, E. & Geiger, B. Molecular complexity and dynamics of cell matrix adhesions.
In vitro studies often use purified ECM proteins for cell culture coatings, however these may not represent the molecular complexity and heterogeneity of the brain's ECM.
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood.
However, it is important to recognize that reproducing the molecular complexity and heterogeneity of the ECM in the brain may increase the relevance of in vitro studies6.
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13321_2017_206_MOESM2_ESM.docx Additional file 2. The supporting information contains details on molecular complexities and on molecular morphing threshold optimization.
The hope is that, despite the molecular complexity, oncogenes and transcription factors interact in a predictable way, permitting only a limited number of cell state 'solutions' (Enver et al., 2009).
These reactions that generate two new carbon-carbon bonds in one synthetic step could find important applications in rapidly building molecular complexity from simple and readily available feedstock chemicals, and in making highly diversified carbo- and heterocycles.
He also theorizes about such molecular evolutionary topics as 'selfish DNA', the origins of introns and molecular complexity, lateral gene transfer and the meaning of phylogeny.
Nevertheless, the application of human microarrays in nonhuman primate neuroscience research recovers useful information from thousands of genes, and represents an important new strategy for understanding the molecular complexity of behavior and mental health.
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