Sentence examples for molecular clockwork we from inspiring English sources

To test if the abnormal circadian behavior found in Usp2 KO mice is associated with changes in the molecular clockwork, we studied clock gene RNA expression in Usp2 KO and WT MEFs synchronized with a serum shock, a typical method used to assess molecular clock function in cultured cells.

To understand the mechanisms by which E75 controls molecular clockwork in the s-LNvs and how UNF takes part in this process, we sought to identify the E75 downstream target genes.

To interrogate the mechanistic relationship between the molecular clockwork and network communication critical to the operation of the Drosophila circadian pacemaker circuit, we established new fluorescent circadian reporters that permit single-cell recording of transcriptional and post-transcriptional rhythms in brain explants and cultured neurons.

Figure 3: Time-of-day-dependent modulation of the molecular clockwork by PDF.

Preitner, N. et al. Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators.

There are likely other important neuropeptides and neurotransmitters that link neuronal communication with the molecular clockwork.

The time-of-day-dependent modulation of the molecular clockwork by PDF may also enhance the synchronization of clock neurons.

Several pacemaker neurons and clock genes have now been identified and their roles in the cellular and molecular clockwork established.

Other neuropeptides and neurotransmitters are also involved in circuit synchronization and the coordination of behavioural output21,22; however, their impact on the molecular clockwork remains largely uncharacterized.

Remarkably, dysregulated metabolic and cardiac profiles were not driven by disruption of the molecular clockwork, nor by a loss of phase synchrony between different tissue oscillators (internal desynchrony).

Shemesh, Y., Cohen, M. & Bloch, G. Natural plasticity in circadian rhythms is mediated by reorganization in the molecular clockwork in honeybees.