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Among them, the CLOCK (Circadian Locomotor Output Cycles Kaput) gene, a transcription factors from the positive limb of the molecular clock that forms a complex with BMAL1 (Brain and Muscle ARNT-Like 1), is one of the most relevant [ 14, 30, 31].
By counting mutations in the viral genomes in different blood samples over time, the scientists created a "molecular clock" that estimates how fast the virus mutated.
Nagalingum, Marshall and their colleagues studied all 11 groups of cycads and two-thirds of the world's 300 species, developing a molecular clock that told them how recently living cycads diverged from one another.
Telomeres therefore act as a kind of molecular clock that tells a cell how old it is.
So he came up with a new way to calibrate the molecular clock that relied on Bioko's known separation date from the mainland, and he recruited Worobey to help him analyze the data.
The number of mutations per generation the mutation rate can be used to fine-tune a molecular clock that has long been used to date key events in human evolution.
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Mother Nature, however, seems early on to have hit on one good design for the molecular clocks that govern circadian rhythms and used it repeatedly.
Biotech firm Geron just began human tests of a cancer therapy that targets enzymes that reset telomeres, tiny molecular clocks that tell cells to die after a certain number of divisions; these clocks malfunction in cancer cells.
These rhythmic processes are believed to be driven by endogenous molecular clocks that regulate rhythmic expression of clock-controlled genes (CCGs).
Examination of differences in expression of core clock genes and genes that regulate molecular clocks in mammary and liver, suggest that hypergravity exposure impacted molecular clocks that generate circadian rhythms.
The bases of these oscillations are internal molecular clocks that maintain their rhythm even in the absence of external timing signals.
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