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Consequently, the high divergence of CMS-T might not have occurred in a molecular clock tempo (as suggested by the rejection of the molecular clock hypothesis in the phylogenetic analysis).
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As there is little a priori information on the tempo of evolution within oomycetes, here we estimate divergence times under three distinct molecular clock models: a single-rate strict clock, a relaxed clock with uncorrelated rates modeled under a lognormal distribution (UCLD), and a random local clock model.
1) Molecular clock.
What is a Molecular Clock?
The molecular clock as a metabolic rheostat.
Ayala, F. J. Molecular clock mirages.
Variation in the molecular clock in primates.
Correcting for purifying selection: an improved human mitochondrial molecular clock.
Weir, J. T. & Schluter, D. Calibrating the avian molecular clock.
The molecular clock mediates leptin-regulated bone formation.
The most suitable molecular clock for the data was strict clock (Log10 BF 4.05 over lognormal relaxed clock).
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