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Age estimates were calculated using the molecular clock rate for E. coli as an approximation (3.4×10−9 synonymous mutations/generation) and assuming 300 generations per year, as per the method employed for age estimates in Yersinia pestis [42].
The dating of different lineages split was calculated based on an E. coli molecular clock rate.
The calibrated molecular clock rate places diversification times within Sierra Nevada Grylloblatta lineages during the Pleistocene glacial stages.
Invertebrate mitochondrial genomes have long been assumed to evolve at a standard molecular clock rate of 2.3% divergence/Ma [ 2].
The resulting molecular clock rate fits well with previously used rates in East African cichlids [ 4, 75].
Under this phylogenetic dating approach, we computed the TMRCA of several nodes of interest and, at the same time, estimated the posterior distribution of the molecular clock rate.
Similar(33)
Nevertheless, there are important caveats for the use of molecular clock rates.
The use of molecular clock rates as calibration data, rather than the fossil record, has also been criticised [ 72, 73].
In fact, a time-dependency of the molecular clock rates has been recently proposed and discussed [ 24, 25].
The OsLRR-PSR gene is the true ortholog of IRI-like genes and the incongruent divergence time estimates are caused by differences in molecular clock rates.
In order to obtain a relaxed molecular clock, rates are sampled independently from a Γ-distribution (parameterized by a mean and a variance) for each edge, and an edge with time t and rate r is assigned a length l.
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molecular adsorption rate
molecular response rate
molecular arrival rate
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molecular evolution rate
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molecular clock mechanism
molecular clock assumption
molecular production rate
molecular clock test
molecular divergence rate
molecular diffusion rate
molecular clock method
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