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In the absence of molecular clock information, one might rely on cave ages to place upper limits on cave species ages, but studies have shown that troglomorphic species are sometimes older than the caves they inhabit [60,61; see below].
Given that almost all of our various attempts to date the split failed to converge on any meaningful solution, it seems likely that integrated GRD sequences have not retained enough molecular clock information to enable a more precise estimate of the OW-NW begomovirus split.
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Calibrating a phylogeny with the relaxed molecular clock and fossil information has made substantial progress in the last few years with developments in assessing calibration uncertainty [ 24, 26].
In general, it seems that the combining of phylogenetic and archaeological approaches will be useful for cross-checking data and improvement of human mitochondrial molecular clock estimates, as new information about modern and ancient mitochondrial genomes becomes available [3].
Readings from the molecular clock provide the temporal information needed to reconstruct the emergence and evolution of lineages and transmission events within an outbreak.
Although the previous models for the skeletal pattern formation have proposed the existence of a molecular clock that provides positional information [ 7, 8], there is no evidence for the molecular clock to determine positional values during skeletal development.
Collectively, our phylogenetic and molecular clock analyses, as well as information on isolate frequencies and global geographic distribution, facilitate the most comprehensive description to date of the global diversity and historical transmission patterns of this pathogen.
The great diversity of the "Phytophaga" (weevils, longhorn beetles and leaf beetles) has been attributed to their co-radiation with the angiosperms based on matching age estimates for both groups, but phylogenetic information and molecular clock calibrations remain insufficient for this conclusion.
This molecular clock gives temporal and spatial information on protein turnover.
Fu et al. (2005) found that osteoblasts have a functional molecular clock, and suggested that time information may be carried to bones via a leptin-parasympathetic neuron-bone pathway.
The most suitable molecular clock for the data was strict clock (Log10 BF 4.05 over lognormal relaxed clock).
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