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It has long been suggested that molecular classifications of cancer may have the capacity to transcend organ or tissue-specific definitions.
Many independent teams have proposed molecular classifications of CRC in the past few years.
Recently, GEP based molecular classifications of MM [ 5, 6] and risk predictors have been published [ 13– 16].
Consequently, the developmental classification can be examined to determine how it deals with apparent discrepancies between the morphologic and molecular classifications of neoplasms.
Using the gene expression profiles of robust molecular classifications of HCC published by Hoshida and colleagues, we determined the initial differentially expressed genes [ 7].
The clustering of tumours into different groups that share patterns of gene expression has led to subdivisions and molecular classifications of lung adenocarcinomas in particular [116 120].
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Zhan, F. et al. The molecular classification of multiple myeloma.
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Hans, C. P. et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.
Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
Molecular classification of Crohn's disease reveals two clinically relevant subtypes.
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