Nine types of evidence were examined (Additional file 3): 1/ Differential expression between normal breast tissue and tumors [ 29] (accounting for different known molecular classes of breast tumors [ 52]).
Although combinations of specific molecular classes created unique predictive profiles for each functional measure, glycerophospholipids remained the most common class of molecules to predict responsiveness in the various functional domains.
The multiple roles played by the matrix in the desorption and ionization of large analytes has lead to the optimum choice of matrices for different molecular classes being empirically determined (McDonnell et al. 2005).
For example, within the intermediate region where the majority of signals occur (m/ z 700 to 1000), the class-specific mobility-mass correlations partition into distinct bands which can be subjected to a probability distribution analysis for molecular class information (see, for example, Figure S2, Supporting Information).
This instrument has recently been used to measure absolute collision cross section values in helium and nitrogen, which are important for generating molecular class-specific calibrations for TWIMS studies.
For example, tumors diagnosed as "oligoastrocytoma" were found in all three molecular classes and lacked a defining molecular signature.
Appendix E lists the most frequent terms for Bacteria, Cellular Component, Biological Process, and Molecular Function classes for T4SS, near-miss, and general documents.
The prognosis is good for LN− ER-positive patients independently of any further molecular class and very severe for LN+.
The parameters used for the NPI+ for each of the seven core molecular class are not only different for each class but also incorporate additional well-validated variables such as LVI (Rakha et al, 2012) and PgR (Prat et al, 2013) that were not considered in the generation of the traditional NPI.
