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The prognosis is good for LN− ER-positive patients independently of any further molecular class and very severe for LN+.
Otherwise, there was no association between the molecular class and the histologic type or grade of the tumor.
Proteins were classified based on the Gene Ontology (GO -based molecular class and cellular component features usinGO -basedhouse resource, Humolecularenclassotein dandbase, HPRD (http://www.hprd.org/).
Otherwise, there was no association between the molecular class and the histologic type or grade of the tumor (see Tables 3 & 4).
For both the CoC and OncoSign analyses, the association between molecular class and IDH 1p/19q co-deletion status was far superior to the association between molecular class and histologic class, indicating that these biomarkers were capable of accurately capturing cohesive biological characteristics of lower-grade gliomas in a robust manner.
Gene Ontology-based molecular class and subcellular localization of the identified proteins are shown in Figures 2(A) and (B), respectively, and details provided in Additional file 2: Table S2.
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For example, tumors diagnosed as "oligoastrocytoma" were found in all three molecular classes and lacked a defining molecular signature.
In our series, though it was not designed to study this association, we observed an interesting association between GBMs molecular classes and the response rates.
The diversity in applications allows for integration of interaction data from numerous molecular classes and cellular states, providing insight into the structure of complex biological systems.
This NPI+ was then used to predict outcome (BCSS) in the different molecular classes and the NPI+ outcome prediction was compared with that achieved by the traditional NPI in each of the biological classes.
The presence of a predominant unclassified group also suggests that the currently used molecular analytic spectrum may not completely encompass all molecular classes and there is a need to further refine and develop the existing classification systems.
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