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Components in molecular circuitries include multiprotein complexes that are relatively large and highly dynamic [ 13].
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However, it is increasingly apparent that linear representations are insufficient, and that "canonical" signal transduction cascades are components of an interconnected web of molecular circuitry that includes extensive cross talk among different receptors [ 4- 7].
Such cues activate incentive mechanisms mediated by brain circuitries, including ventral striatum and orbitofrontal and medial prefrontal cortex (3).
The software is designed to identify molecules upstream of regulated tumour proteins to assist in the construction of molecular circuitries.
As the molecular circuitries involved are not yet resolved, current otoprotective therapies are rather empirical than rational.
CDDP resistance is often multifactorial, as it relies on the simultaneous activation of multiple, non-redundant molecular circuitries.
Finally, to gain insight into the molecular circuitries of EGFR induced hepatocarcinogenesis diverse computational approaches were employed.
Nevertheless, the molecular circuitries underlying EMT and stemness appear closely intertwined, and it will be vital to further delineate key molecular players that link these two cellular states.
The highly orchestrated molecular circuitries that ensure normal functioning of each cell are disrupted in cancer, making it a disease of uncontrolled cell proliferation.
In our initial study we reported the oncogenomics and pathology of EGF induced hepatocarcinogenesis and an identification of molecular circuitries linked to exaggerated EGFR signalling [ 6].
In this article, we will examine the molecular circuitries that link cellular stress and death, and how these pathways can get uncoupled during hormetic responses.
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