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This concern prompted research conducted by Fouchier and colleagues and Kawaoka and colleagues, with funding from the U.S. National Institutes of Health (NIH), to understand the molecular characteristics underlying transmissibility.
Recent re-classification of many diverse histological entities into ETMRs prompted a view into the molecular characteristics underlying these aggressive tumors of the early pediatric years [ 40].
Given the differences in clinical manifestations between these subtypes of myositis and the lack of optimal efficacious therapies for these diseases, understanding the molecular characteristics underlying their subtypes may facilitate the development of novel therapeutics that could benefit patients with myositis.
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The aim of the current study was to evaluate the molecular and cellular characteristics underlying the synergistic cytotoxicity observed between new targeted agents and the carboplatin pemetrexed combination through an in vitro assessment of their pharmacologic interaction.
Nevertheless, the underlying molecular characteristics of micrometastatic cells associated with the development of overt metastases remain largely unknown.
The option of treatment depends upon tumor histology, stage, molecular characteristics, performance status, and underlying diseases [ 1].
Our results also imply that the use of cell models for microRNA functional studies in cancer research demands careful assessment of underlying molecular characteristics for proper data interpretation.
Accordingly, the functional genomics approach is one of the useful ways for describing some of the molecular characteristics of neuronal changes underlying normal aging and neurodegeneration [ 30, 62- 65].
Results indicate that the use of cell models for cancer research demands careful assessment of underlying molecular characteristics for proper data interpretation.
The development of trials that begin to match treatment arms to underlying molecular characteristics (e.g., FOCUS3) should be widely supported and further developed.
The IDH1 story illustrates how metabolomics can help researchers understand the molecular characteristics of lesions that underlie human disease.
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