Sentence examples for molecular characterisation to from inspiring English sources

Phase I/II clinical trials with these agents should include pharmacodynamic endpoints and molecular characterisation to identify patients most likely to benefit from this strategy.

Phase I/II clinical trials with these agents should include further pharmacodynamic endpoints and molecular characterisation to identify patients most likely to benefit from this strategy.

Samples of outlier patients considered as 'exceptional responders' or as 'rapid progressors' based on the clinical follow-up will be subjected to deeper molecular characterisation in order to identify new prognostic and predictive biomarkers.

Given the high incidence of HRV infections and ongoing exposure to other circulating (sero types, molecular characterisation is required to clearly document HRV persistence [27].

In addition to these pathological prognostic factors, which can only be identified post-surgically, molecular characterisation is expected to improve the identification of more aggressive or treatment-resistant tumours before therapy.

Identified more than a century ago as the primary constriction of condensed metaphase chromosomes, the centromere remained elusive to molecular characterisation for many years owed to its unusual enrichment in highly repetitive satellite DNA sequences, except in budding yeast.

As they may also have a better prognosis, the molecular characterisation may prove to be useful in selecting those patients in whom adjuvant imatinib is truly required.

The development of novel targeted therapies has created the need for molecular characterisation of cancers to allow more appropriate treatment decisions.

Taken all together, our data demonstrate that OSPC and USPC, two diseases where further molecular characterisation is needed to improve differential diagnosis and therapeutic strategies, can be readily discriminated solely by gene expression profiles.

Consent from referring laboratories was obtained for seven of these isolates to be subjected to molecular characterisation.

CTC enumeration can serve as a 'liquid biopsy' and an early marker of response to systemic therapy, whereas their molecular characterisation has a strong potential to be translated to individualised targeted treatments and spare BC patients unnecessary and ineffective therapies (Lianidou et al, 2012).