Sentence examples for molecular changes with from inspiring English sources

The goal was to determine whether there is an association of methylphenidate-induced molecular changes with particular corticostriatal circuits (functional domains).

We also describe the role of PD analyses in clinical trials, including for MOA confirmation and dosage regimen optimization during phase 0 trials as well as for correlating molecular changes with clinical efficacy when establishing proof-of-concept in phase I/II trials.

Figure 5 shows a schematic of a biosensor fabrication setup designed to mediate various molecular interactions and to identify minuscule molecular changes with high sensitivity.

Correlating molecular changes with tumourigenesis has provided one route to the identification of potential drug targets and provides the rationale behind efforts to characterise genetic variation and gene expression in tumours.

It is therefore difficult to associate molecular changes with specific physiological events.

For instance, both models display profound morphological and molecular changes, with cells showing EMT features and invasive/migratory capacity.

In our study, the molecular changes associated with alterations of structural molecules and with the composition of the extracellular matrix were also shown in the protein levels.

The molecular basis of this phenotypic difference was demonstrated by showing TG-resistant cells had lower levels of HPRT mRNA than cells treated with Dox (Fig. 3) and molecular changes associated with epigenetic silencing (Figs. 4, 5, and S2).

These changes were consistent with ion beam damage of the polymer chain and later show molecular changes consistent with mild pyrolysis of the fibres.

This may be because dynamic molecular changes occur with therapy.

van Raemdonck, D. et al. Molecular changes associated with the setting up of secondary growth in aspen.