Sentence examples for molecular changes such from inspiring English sources
Tumor progression is a complicated biological process that comes with enormous genetic and molecular changes, such as chromosome aberration, gene mutations, and activation or inhibition of transcriptional pathways.
Similar to other molecular changes, such as plasma protein profiles [ 44], this urine peptide panel may detect incipient SJIA disease activity prior to clinical evidence of disease.
Each of these imatinib-induced changes resulted in characteristic intracellular metabolite patterns and showed good correlation with molecular changes such as protein expression.
The ability to measure molecular changes (such as phosphorylation of receptor tyrosine kinases associated with drug target interactions before and after therapy) can provide early proof of whether the biologic agent has successfully reached its hypothesised target.
Gorre et al (2001) clearly demonstrated cell intrinsic mechanisms of resistance to Glivec® whereby cells taken from relapsing patients showed reduced sensitivity to the drug with evidence of acquired molecular changes such as gene mutation or amplification.
It is thought that metabolic memory is the result of long-term molecular changes, such as flux through the polyol and hexosamine pathways and activation of protein kinase C [ 18], as well as oxidative and nitrosative stress [ 19].
To examine the characteristics of tumour cells with both the molecular change such as overexpression of TrkB and the morphological change such as tumour budding or tumour cell dedifferentiation, immunohistochemistry using whole-tissue sections seems to be useful.
At all levels of processing, significant cellular and molecular changes occur, such as large alterations in the transcriptional profile of these tissues [ 67].
Molecular changes in such PTC have not been widely studied, and it is presently unclear whether they have similar and/or distinct molecular characteristics compared with PTC in other populations.
We then discuss sensorimotor training effects in humans, specifically the Quadrato Motor Training (QMT) effects on brain connectivity, cognitive function, and structural and molecular changes, supporting such a multimodal cerebellar-cognition relationship.
These findings are consistent with known diabetes-induced cellular and molecular cardiac changes, such as structural, metabolic and signaling perturbations [5].
