Sentence examples for molecular changes observed from inspiring English sources

Taken together, the concept of EMT is a valuable model for the morphologic and molecular changes observed in tumor cell invasion as well as tissue fibrosis.

For ease of reference and to highlight the significance of the molecular changes observed, the molecular characterization results that appear most relevant are discussed in this section.

Since the time point for the molecular changes observed is five days after exposure, it is also possible that the changes represent secondary intermediate modes of change rather than specific early mechanistic interactions.

Although increased DNA methylation was one of the molecular changes observed at silenced promoters in our system, DNA methylation was not required for the initiation of silencing because 5-aza-dC treatment had no effect on the frequency of silenced clones induced by Dox treatment.

In our previous phase I study using hydralazine at doses between 50 and 150 mg/day without accounting for acetylator phenotype, we observed demethylating and reactivating effects [46]; hence, the levels observed herein readily explain the molecular changes observed regarding methylation and gene expression.

The aim of this study was to explore whether the abnormal molecular changes observed in the matrix of OA subchondral bone can be identified with Raman spectroscopy.

Such extension predicts the seemingly paradoxical pattern of phenotypic and molecular change observed in experiments.

In addition, TG9 mice exhibit many of the salient molecular and functional changes observed in human heart failure including elevated brain natriuretic peptide levels and a positive response to beta blockers and ACE inhibitors [9].

In addition, we cannot rule out the possibility that the molecular changes specifically observed in dynorphin positive medium spiny neurons may be due to the direct synaptic interaction with DA neurons in the ventral mesencephalon.

These molecular changes are observed in both cancer and aging, and this supports the notion that chronic oxidative damage to DNA might trigger cancer and promote aging [10], [11].

Although no further significant differences in other parameters were noted, substantial molecular changes were observed in toxicogenomic profiles.