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Individual TG-resistant clones were characterized to identify molecular changes correlating with PTRE-HPRT inactivation.
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To explore if dynamic, targeted-therapy-driven molecular changes correlate with mccRCC outcome.
Although many molecular changes correlate with aging, the presence of senescent cells capable of secreting inflammatory cytokines may be involved.
Further work is required to fully assess how the response to different hormonal therapies and short-term molecular changes correlate with long-term outcome.
These molecular changes correlate well with WA-induced dose- and time-dependent alterations in cell viability and apoptosis, suggesting that these are key factors involved in the anti-cancer effects of WA.
This report describes the development and characterization of this model and our studies investigating molecular changes that correlate with metastatic potential.
Since identified molecular changes do not correlate with histomorphological alterations in general, a major role of Claudin-1 as of the other four tight junction-related proteins in the pathogenesis of GERD can not be concluded from our study.
Using this approach, we observed that functional changes correlated well with the overall level of TGI, whereas molecular or morphological changes showed a poor correlation.
In an effort to get better insight into the molecular pathways associated with the activation of CG genes in tumors, we undertook transcriptomic analyses aiming at identifying gene expression changes correlated with CG gene activation.
These changes correlate with the dissociative identity disorder (D.I.D).
These changes correlated well with contraction strength.
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