Thus we applied GO categorization of molecular function to genes up- or down-regulated in each mutant (in Additional file 3).
The Al-responsive group consisted of 103 genes, and included a significantly higher percentage of genes encoding proteins with transporter (10.7%) and transferase (16.5%) activities, by GO categorization of molecular function.
MiRNA composition and expression levels have been used as a molecular taxonomy approach for categorization of tissue types, description of cellular physiological states and even classification of disease states [ 33].
Over the past 20 years, immunohistochemistry has added a molecular dimension to the categorization of mammary neoplasms: altered expression of oncogenes, oncosuppressor genes, hormone receptors, and cytoskeletal proteins have been identified as useful indicators of disease outcome.
This group contained a significantly larger percentage of genes with "other binding" activity by GO categorization of molecular function (Table 1), including six Ca-binding proteins, such as calmodulin-like proteins (CML38 and 37/39) and Ca-binding EF hand proteins, which were rare in other gene groups (Additional file 4).
Therefore, we manually updated our previous functional categorization of genes into molecular categories [ 7] and, when possible, subcellular categories.
Gene lists were mapped to PANTHER for categorization of genes to molecular function and biological processes, as well as to biological pathways (http://pantherdb.org).
Categorization of breast cancer by molecular signatures enhanced the ability of pCR to predict improvement in RFS compared to the population as a whole.
Layer 2 provides a more detailed categorization of the pathways involved in molecular adaptation of plants to drought stress.
In addition, whole-genome gene expression profiling has enabled categorization of tumors into the intrinsic molecular subtypes luminal A, luminal B, HER2-enriched, basal-like and normal-like [ 31].
