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Transmission electron microscopy images of the composites after 6 weeks of culture indicated that collagen fibrils in the fibrous tissue layer were well integrated into the collagen network of the cartilage disk and ring, whereas molecular bridging between opposing disk/ring cartilage surfaces was less pronounced and restricted to regions with narrow interfacial regions (< 2 μm).
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Noller's team found about 30 molecular bridges between the subunits, up from the six first discerned in the mid-1990s.
As a novel strategy, we propose to modify existing copper(I) complexes by introduction of molecular bridges between the different ligands.
Through these activities, IKKγ forms a molecular bridge between IKK, its upstream activators, and its substrate.
These complexes help the formation of molecular bridges between the actin cytoskeleton, integrins and focal adhesion complexes within ruffles and pseudopodia and are critical for cell movement [6].
In addition, heparan sulfates bind efficiently to various extracellular matrix proteins and play an important role in mediating molecular bridges between the ECM proteins and between cells and ECM proteins through their heparin binding sites.
Furthermore, we showed that adhesion to ECM components was inhibited by heparin and heparan sulfates (HS) suggesting that in vivo, HS could function as a molecular bridge between the matrix and S. aureus expressing the LukS-PV signal peptide.
The main ligand for this GpIb/IX/V complex is von Willebrand factor (VWF), a multimeric plasma protein that functions as a molecular bridge between components of the exposed subendothelial matrix (in particular collagen) and the platelet GpIb/IX/V complex.
The model predicts that Lck therefore provides an essential molecular bridge between CD28 and PKCθ.
Thus, it might function as a molecular bridge between telomeric DNA and TERRA.
Thus, Akirin might act as a molecular bridge between BAP60 and several other transcription factors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com