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The development of next-generation sequencing (NGS) technologies and bioinformatics has greatly facilitated studies on molecular biological changes and regulation at the genome-wide level, especially for non-model plants (Chai et al. 2009; Ward et al. 2012).
Analysis of molecular biological changes in lipomatous tumors has provided new expert information in liposarcoma management.
Understanding the molecular biological changes underlying the process of epileptogenesis is crucial to the development of newer, more effective treatment regimes.
Continuing study of the Chernobyl-related tumours should allow continuing correlation of molecular biological changes with tumour growth rates, morphology and aggressiveness and may enable treatment to be individualised in a way that is not currently possible.
The findings that stressors may be able to activate the release of pro-inflammatory cytokines and an acute-phase response in the absence of an immune challenge further support the notion that the immune system may be recruited to participate in the behavioural response to stress and therefore may contribute to the biochemical and molecular biological changes that characterize depression.
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And now, the clinical dividing of less than or equal to and more than 1/2 of the whole layer in invasive depth may be too rough to detect the molecular biological change that happened in cells of early stage in tumor progression.
Evidence from non-traumatic degenerated discs further suggest concomitant complex molecular and biological changes [ 2].
As advanced-stage OSCC has a poor prognosis [ 1], understanding the molecular and biological changes of its progression is critical to development of more effective therapies.
Aging is a multifactorial process that is characterized by distinct molecular and biological changes, such as increased genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence and altered intercellular communication [ 1].
Biochemical, cytological, molecular, biological, and genetic changes were induced as a result of antibiotic action.
Recent reviews point out the usefulness of combining advanced imaging methods, in particular PET in conjunction with MRI, to visualize additional molecular information and biological changes of the tumour [ 41, 42].
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