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In line with this molecular basis, we further provide evidence that the combination of IFN-γ and an IDO1/AhR inhibitor effectively disrupts dormant TRCs, leading to a novel tumour immunotherapeutic strategy with potential clinical applications.
It is clear that, as further studies understand how this encapsulated yeast is able to withstand the stresses of high temperature at a genetic and molecular basis, we will also know more about how it and other fungal pathogens have evolved into well-established human pathogens.
On the same molecular basis, we also constructed vectors for the expression of shRNA which inefficiently targeted GFAP or vimentin.
Without knowing the molecular basis, we based our identification of VRAC on the physiological criteria described from various other cell types [4], [45], [46], [47].
Toward elucidating this molecular basis, we have characterized the eukaryote and insect proteomes.
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To address the molecular biology basis, we combined results from both basic (animal model 17– 21) and human clinical studies.
While we understand some aspects of the molecular basis of resistance, we understand less about the mechanisms that drive the evolution of drug resistance and overall pathogenicity in C. albicans.
To further understand the molecular basis of steatosis, we employed a multi-omic approach to characterize the steatotic phenotype.
To understand further the molecular basis of angiogenesis, we have exploited β3-null endothelial cells to identify novel genes that regulate angiogenesis.
We wanted to investigate the possible molecular basis of the effects we observed.
To overcome this problem and to increase our knowledge of the molecular basis of Usher syndrome, we designed a targeted resequencing custom panel.
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