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However, the underlying molecular basis was unknown.
The results for the two cases were almost identical, since similar phenotypes contributed most if not all of the reference genes, even when the molecular basis was known.
Genotyping the different isolates to connect cases on a molecular basis was not possible because the number of oocysts detected in stools was small.
Finally, a conversion of about 68% based on the production of Neu5Ac from GlcNAc on a molecular basis was achieved in 80 h, corresponding to a volumetric productivity of 0.52 g Neu5Ac l-1 h-1.
While clinical case reports of PC date back to 1906, 1 and possibly earlier, the understanding behind the genetic basis of PC was not elucidated until 1994, 2 following discoveries resulting in epidermolysis bullosa simplex (EBS) being the first keratin disorder for which the molecular basis was identified.
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Molecular diagnosis, telling the story of the disease through the genes involved, is not necessary to accomplish the first goal of patient care; diseases are often diagnosed and satisfactorily treated even when the molecular basis is unknown, and discovering the genes involved does not always improve patients' lives.
However, the molecular basis is still not well understood.
Migraine is the most common neurological disorder, but the molecular basis is still not completely understood.
Although the accumulation of quantitative resistance loci could contribute to achieve durable resistance (Poland et al. 2008), its molecular basis is still largely unknown in contrast to the gene-for-gene resistance model.
Such conditions are associated with alterations in fronto-subcortical circuits, but their molecular basis is far from clear.
Other cattle breeds also show inherited diseases affecting the nervous systems but the molecular basis is unclear [2].
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