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Distinct mechanisms of Nrf2 activation by seemingly harmful and beneficial reagents provide a molecular basis to design Nrf2-activating agents for therapeutic intervention.
The structure resolution shows that the enzyme has a dimeric arrangement and provides a molecular basis to identify the residues involved in each catalytic activity.
Nonetheless, models of petroleum refining processes must have a molecular basis to be useful in predicting the molecular composition of products and their physical and quality properties required by industry specifications.
If we understand the structural rules governing antibody (Ab)–antigen (Ag) interactions in a given virus, then we have the molecular basis to attempt to design and synthesize new epitopes to be used as vaccines or optimize the antibodies themselves for passive immunization.
Superimposition of our Pol31 model on the 3D architecture of the phylogenetically related DNA polymerase α (Pol α) suggests that Pol3 CTD interacts with the conserved region of Pol31, thus providing a molecular basis to understand the defects associated with pol3-ct.
Engineering synthetic hydrogels on a molecular basis to introduce natural features that are important in instructing cell behavior is becoming increasingly crucial in biomaterial-based approaches for regenerative medicine and in cell biology to study cell matrix interactions in three-dimensions (3D).
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Only simulated patients corresponding to a syndrome with a known molecular basis, according to the OMIM database, are considered in the subsequent steps of the analysis.
Those previous approaches were, however, restricted to individual brain diseases so that identification of molecular basis common to multiple brain diseases was difficult.
However, the underlying molecular basis related to the change of carotenoid content needs further study.
This study also provides a molecular basis as to why isoflavones are significantly poorer inhibitors of aromatase than flavones.
This suggests that the co-occurrence of +14/-22 +14/-22-16q imbandnces should confer a selective advantage, whose molecular basis remains to be elucidated.
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