A comparison of molecular based classifications reveals that 7 major clades are repeatedly found.
In the last several years, microarray technology has been used to generate gene expression data for hundreds of tumor samples and provided a new paradigm of molecular based cancer classification.
(PDF 908 KB) 13065_2012_596_MOESM2_ESM.xls Additional file 2: Table S1: Simple molecular properties of M.tb inhibitors and their rules based classification.
It also emphasizes a justifiable need for replacing current morphology based classification systems of breast cancer by a molecular classification that may be more relevant prognostically [ 7].
Differentially expressed mRNAs between follicular adenomas and carcinomas can be a good indicator in such molecular-based classification.
A molecular-based classification of MB is a crucial step towards optimized treatment schemes aiming at improving risk-benefit therapeutic profiles.
The molecular-based classification, recently adopted for breast cancer, seems to be a better tool than morphological features to establish objective similarities between the two models.
Our study showed that the molecular-based classification of canine mammary cancer was related to grade, but not to invasion and morphologic classification.
Application of the molecular-based classification system provides additional information on the different cell origin of basal-like and luminal-like tumours.
Our investigation failed to disclose any association between the molecular-based classification system and survival, whereas Gama et al. [ 34] found only the basal-like group significantly associated with a short survival.
Gene expression profiles using cDNA microarrays have been used to derive a useful molecular-based classification for the diagnosis, treatment, and prevention of several cancers (Alizadeh et al, 2000; Bittner et al, 2000).
