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The use of multilayered polymeric films offers the possibility of creating multicomposite molecular assemblies with great levels of reproducibility and controlled molecular architectures.
Therefore, we propose that disordered protein granules, even those made of aggregation-prone prion-like domains, are dynamic and disordered molecular assemblies with transiently formed protein-protein contacts.
The ability of the occluded Pluronic P123 mesostructures to solubilize organic molecules made these films ideal host matrices for organic dyes and molecular assemblies with substantial nonlinear susceptibilities due to exiton dynamics in film structure.
The outstanding sensitivity provided by the single-mode EA-IOW is expected to help in studies of redox couples with small differences in their extinction coefficients, molecular assemblies with low surface densities, or adsorbates with a low number of electro-chemically active species.
As a consequence, the amplitude of the ac optical response is often too small to be detected either (i) for a redox couple with a small difference in their extinction coefficients or (ii) for molecular assemblies with low surface densities, or (iii) for an adsorbate with a low number of electro-chemically active species.
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In both organometallic catalysis and organic, drug-like chemical space, several attempts have been made to increase diversity by combining automated molecular assembly with structural descriptors.
The current generated by the binding of NADH, the electron donor, was transduced through the molecular assembly with apparently little loss of signal to the solution.
Learning how to recognize, understand, and, ultimately, manipulate such processes will be an important step towards mimicking nature's mastery of molecular assembly with synthetic systems.
The differing stiffness regimes observed are far from trivial since protein backbones are almost identical in their molecular assembly with only the filament architecture as the main factor for the resulting mechanical properties.
Molecular profiling, combined with biophysical modeling of molecular assemblies associated with the disease, offer an opportunity to link the molecular pathway changes with cell- and tissue-level physiology and structure.
Construction of the molecular assemblies was performed with the VMD program [44].
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