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One of the most important applications of global optimization is to find the global minima of the potential energy of molecules or molecular assemblies, such as crystals.
Biological systems offer inherently good examples for phenomena in nanotechnology, since the length scales of functional molecular assemblies, such as protein complexes and membrane fragments, fall in the 5 10-nm range.
This article is a brief tutorial dealing with the conceptual aspects of (i) excitation transfer in molecular assemblies, such as occurs in the early steps of photosynthesis, (ii) radiationless transitions, which are ubiquitous participants in the light induced isomerization reactions that support vision and (iii) active control of product selection in a chemical reaction.
By contrast, for very large molecular assemblies such as amyloid fibrils, Deff can include contributions from rotational diffusion such that Deff > Dtrans for small values of Δ (31).
The same concept is manifested in a reported kinetic simulation of a simple network of replicating peptides [ 61], as well as in mutual interaction within molecular assemblies such as monolayers and 3-dimensional crystals ([ 12] and references thereof).
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While some investigators observed toxicity of low molecular mass oligomers, such as dimers and trimers, a strong correlation between higher molecular mass assemblies, such as dodecamers, and AD-linked synaptotoxicity has been reported by others.
Such finite molecular assemblies can display function, such as host guest behavior and chemical reactivity.
Biomimetic materials cannot properly mimic such synthetic processes and use machines to assemble structures, but there are ways in which such molecular assemblies could be introduced, for instance by using a 'spinneret' based on that found in a spider or caterpillar in a rapid manufacturing machine.
Following the pioneering work in the 1960s of De Rosier and Aaron Klug, cryoelectron tomography is now beginning to allow to make visible complex molecular assemblies within a living cell, such as actin bundles, intermediate filaments, which build the scaffold of a cell.
Nanostructured semiconductors, organic-inorganic hybrid assemblies, and molecular assemblies present new opportunities to design such third-generation light energy conversion devices.
Introducing different triggers into such systems creates molecular assemblies capable of performing logic gate operations and/or catalytic activity control.
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