Thanks to the advances of genomic and molecular analysis techniques, and systemic analysis tools, microorganisms able to produce a variety of biofuels and chemicals from lignocellulose and other substrates, with production capacities in magnitudes orders higher than native ones, are currently available in the literature.
High-throughput molecular analysis techniques nowadays yield datasets with a size and complexity at which they are no longer directly interpretable by humans.
A central tenant of the new toxicology involves applying modern molecular analysis techniques to elucidate mechanisms of toxicity and is being enabled by several factors.
The impact of dietary interventions on the human intestinal flora and the role of the fecal flora in rheumatic diseases have to be clarified with newer molecular analysis techniques.
The manipulation of HAS expression and HA metabolism via long noncoding RNAs such as HAS2-AS1 and/or microRNAs, together with recent advances in molecular analysis techniques, hold much promise in these contexts [ 50– 52, 122– 128].
Molecular analysis techniques suggest that many ESBLs are derived from mutations in TEM-1, TEM-2, and SHV-1 β-lactamases and that these ESBLs can hydrolyze the extended-spectrum cephalosporins (particularly ceftazidime) and aztreonam (1 ).
In order to overcome these limitations but still use the wealth of information generated by genome-scale molecular analysis techniques, an integrative approach is proposed to search for putative tertiary therapeutic targets in human cancers.
We recognize that classification of isolates and nomenclature for Corynebacterium may have changed over the time period that is encompassed by the source publications included in our analysis, and that new molecular analysis techniques have led to the reclassification of some isolates, and may impact our findings.
The current climate is one of technological innovation, with major leaps forward achieved not only in the accuracy and efficiency of NGS platforms and other large-scale molecular analysis techniques (proteomics and metabolomics), but also in the associated tools and concepts for analyzing the resultant omics data.
