Sentence examples for molecular alterations such from inspiring English sources

Multiple cellular and molecular alterations such as amplification or overexpression of oncogenes, hypermethylation or mutation of tumor suppressor genes, activation of cancer stem cells, and infiltration of immune cells, contribute to the malignant transformation of HCC.

Other molecular alterations such as KRAS and BRAF mutations do not seem to be associated with PPARG methylation, while a correlation with the microsatellite instability status was found (Figure S1) [10].

This hypothesis is based upon morphological transitions of atrophy to PIN, and at times directly to micro-invasive adenocarcinoma, and rare molecular alterations such as methylation of GSTP1 [23] and telomere shortening [24].

Structural variants include a variety of molecular alterations such as duplications, deletions, and inversions [ 9, 10].

Colon cancer development is a multistep process initiated by molecular alterations such as mutations in adenomatous polyposis coli (APC), K-ras, and/or p53 genes [ 3].

To date, there is not sufficient evidence for selecting patients for PI3K inhibitor trials on the basis of specific molecular alterations, such as PIK3CA or PTEN mutations.

Molecular alterations underlying such mechanisms comprise aberrations on the genetic level, such as point mutations of distinct genes, or amplifications and deletions, while others result from epigenetic modifications such as aberrant methylation of CpG islands in the regulatory sequence of genes.

To examine this hypothesis, we have decided to study losses of – or molecular alterations in – such AC proteins with respect to their effects on myocardiac organization and functions.

This analogy provides leads for unravelling the molecular alterations in such cancer-prone human cells.

In our series of patients with T4 breast carcinoma, no statistically-significant correlation between any of the analyzed molecular alterations and such pathological parameters was inferred.

Each alteration is annotated through some features - that vary according to the type of molecular alteration - such as the contig number, the direction of gene expression variation (up/down), the experimental method used, the cancer type or the cell line.