Sentence examples for molecular alterations seen from inspiring English sources

We hypothesise that certain molecular alterations seen in metastatic cells can also contribute to resistance to chemotherapy, and targeting these features might enhance the efficacy of current treatments.

The present study suggests that POU3F2 expression dips during adolescence in the prefrontal cortex (q = 0.025) and may provide a link between the hormonal control of puberty and the molecular alterations seen in this developmental period.

Although these causes could describe possible etiologies, they do not completely explain the cellular and molecular alterations seen in and around the rotator cuff, such as chondrogenic transformation and ectopic mineralization of the tendon tissue.

Kidney cysts display a reduced frequency of primary cilia and atypical cysts and neoplasms exhibit a pro-proliferative signature including activation of mTORC1 and high expression of Myc, mimicking several cellular and molecular alterations seen in human ccRCC and its precursor lesions.

The association of TERT promoter mutations with other molecular alterations commonly seen in glioma is detailed in Supplementary Table 5 and Supplementary Figure 1.

The overlap in the clinical, biochemical, molecular-cellular, and pathological alterations seen in patients with AD and individuals with many other brain disorders, which has bewildered many investigators, may now be explained by the shared underlying mismetabolism of brain ChEs.

Third, the molecular, proliferative, and cell-specific changes observed in the parous (or E+P-treated) mouse recapitulate the parity-related alterations seen in the rat.

Acquired genetic alterations seen in tumors include APC and MCC on chromosome 5q, KRAS on chromosome 12p, DCC on chromosome 18q, GTBP (hMSH6) on chromosome 2p, and p53 on chromosome 17p. 2 In addition, development of these genetic alterations may be accelerated by molecular instability or chromosomal instability.

These serrated polyps include not only hyperplastic polyps but also traditional serrated adenomas and sessile serrated adenomas: these polyps demonstrate characteristic molecular alterations not commonly seen in colorectal adenomas, and they probably progress to colorectal cancer by means of a new pathway: the serrated neoplasia pathway [ 31].

For more detailed discussion of these alterations, see [ 68, 105].

While limited by the nature of in vitro cultured neural cells we have seen that molecular alterations induced by CMP may in-part mirror those molecular changes seen in brain tissues that have experienced long-term stress.