Sentence examples for molecular alterations present from inspiring English sources

In addition, we tested the interaction with tamoxifen for a composed variable, defined as any of these molecular alterations present versus no molecular alteration.

Subsequent improved understanding of the molecular alterations present in the cancer cell has enabled the development of targeted therapies for some forms of cancer.

13 14 16 However, while the mutation-targeted therapy in other malignancies is driven by the findings of the precise molecular alterations present in the tumour, no such study has been conducted in malignant NETs.

The correlation between PTGS2 expression in primary CRC and CRCLM may indicate that protein levels in CRCLM are to a certain extent predetermined by molecular alterations present in the primary CRC.

(2) While the choice of targeted therapies in other malignancies is more frequently being driven by the findings of the precise molecular alterations present in the tumour, no such study has been done in NETs.

Our comparative analysis of the physiological and molecular alterations present in Arabidopsis prmt5 and prmt4a 4b mutants clearly shows that, in plants, the type II arginine methyltransferase PRMT5 and the type I methyltransferases PRMT4a and 4b most often co-regulate the same biological processes, affecting them in a similar manner.

Death from prostate cancer is due to resistance to therapy (i.e., androgen-independent growth) that depends on acquired molecular alterations not present at the time of first diagnosis.

This finding further reinforces that the molecular alterations are already present before the lesion exhibits morphological changes [ 10].

Unfortunately, it was not possible to detect concomitant molecular alterations in the present case, but oncogenic drivers out of EGFR may explain the resistance to EGFR-TKI in EGFR-mutated SCLC.

We chose protein ubiquitination as a target for further analysis due to its versatile role in many aspects of cellular homeostasis and, e.g., the replicative potential of a cell and as it therefore may in fact underlie several of the previously presented molecular alterations in asbestos-associated carcinogenesis.

For example, certain molecular alterations appear to be present in higher frequencies or unique to certain sites/subsites: these include PIK3CA mutations that are more prevalent in human papillomavirus (HPV -induced oropHPV -inducedncer, and alteratioropharyngeal MLL4, ARID2, UNcancerand TRPM3 in gingivalterationsncers [ 18, 21, 22].