Sentence examples for molecular alterations during from inspiring English sources

In view of the primary role of the liver in energy conversion, the present study was designed to investigate changes in hepatic morphology and molecular alterations during PCM.

This provides a rich resource for the analysis of biomarkers and sequential molecular alterations during disease progression.

Alternatively, key molecular alterations during epileptogenesis can be examined in animals subjected to classical models of experimental epilepsy.

In our study CC cells adopted several cellular and molecular alterations during the prolonged treatment with L-OHP which led to resistance to this drug.

However, the precise timing of molecular alterations during tumorigenesis and how these changes to the breast epigenome may influence the risk of becoming invasive cancer remain incompletely defined.

The interactions between the virus and host cytoskeletons such as actin filaments, microtubules, and intermediate filaments have provided insight into molecular alterations during the virus infection, such as viral entry, in-cell transport, scaffold assembly, and egress.

The latter finding was most evident in non-tumor tissue, likely reflecting the widely recognized field-cancerization effect by smoking,[22] while in the tumor tissue, smoking-related genes' effects on survival may be masked by extensive molecular alterations occurring during tumorigenesis.

It is clear that pronounced molecular alterations occur during the normal to DCIS transition; however, genetic alterations to explain the divergent gene expression patterns between in situ and invasive breast carcinomas have not been observed [ 25].

In contrast, due to numerous molecular alterations arising during the course of malignancy, a tumour is characterized by an abnormal response to its environment, which allows cancer cells to evade the normal mechanisms controlling cellular proliferation.

In total, the clinical and basic research literature clearly supports the hypothesis that some retinal molecular alterations induced during a period of poor or no control cannot be reversed by subsequent good glycemic control and that other molecular alterations are not prevented from developing after initiation of insulin replacement.

Although studies of H. contortus have shown that the pattern of transcription differs between free-living and parasitic stages [ 12- 14], there has been no detailed study of the molecular alterations occurring during the early phase of transition to parasitism in this parasite, although there is some information for the canine hookworm, Ancylostoma caninum [ 15- 18].