Sentence examples for molecular alterations contributing from inspiring English sources

However, the molecular alterations contributing to asthma remain unknown.

Genetic heterogeneity is a feature of NSCLC, with varying combinations of multiple molecular alterations contributing to tumour development [ 1].

The high mortality rate from breast cancer metastasis has led to the intensive search for molecular alterations contributing to metastatic progression, with the aim of designing targeted therapies (Dillon et al, 1998; Hortobagyi, 2000).

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown.

Inactivation of tumor suppressor genes by aberrant methylation of cytosine residues in the promoter region is an important molecular alteration contributing to the development and progression of malignant tumors [1].

In women, primary ovarian sarcomas are exceptionally rare [36], with very little known regarding the molecular alterations that contribute to their development.

However, not all patients with HPV infection develop invasive cancer, implying that additional molecular alterations may contribute to the multistep carcinogenesis process.

Collectively, these molecular alterations likely contribute to the delay in differentiation of cells leaving the basal layer resulting in a failure to adopt a proper spinous morphology and to apparent duplication of the basal layer.

In conclusion, this review summarises potential molecular alterations that contribute to metastasis in OS and gives an overview of (pre clinical efforts to develop new therapeutic targets for the treatment of metastatic OS.

Howard I Scher (Memorial Sloan-Kettering CaNew Yorkter, NYw York, NY, USA) described the application of CTCs as a 'liquid biopsy' in the evaluation of two therapies directed at specific molecular alterations that contribute to the progression of castration-resistant prostate cancer, the 17,20-lyase 17,20-lyasebinhibitor, abiraterone, andovel anti-androgen [ 15].

Nickerson, M. L. et al. Somatic alterations contributing to metastasis of a castration-resistant prostate cancer.