Sentence examples for molecular alteration with from inspiring English sources

The number of lobular carcinomas showing E-cadherin mutations varies between studies and no doubt reflects pathologist behaviour; diagnosis historically has been made utilising the full suite of features detailed above, but awareness that E-cadherin inactivation as a major molecular alteration with consequent cellular discohesion may have influenced more recent diagnostic behaviour.

The association of molecular alterations with patient prognosis is also discussed, but it should be remembered that further validation is required in prospective clinical trials utilizing uniform treatment approaches.

This review discusses the current knowledge of these molecular alterations, with a focus on the use of cabozantinib in patients with thyroid cancer.

The model of breast cancer progression via sequential acquisition of selectively advantageous molecular alterations with morphologically recognizable phenotypes is a convenient conceptual framework.

(66) Although the potential clinical value of array-based analysis of molecular alterations in non-tumor liver tissue to clarify the risk of hepatocarcinogenesis is still not well characterized, the association of such molecular alterations with HCC patient prognosis has been increasingly investigated.

Although, CIMP+/MSI-and CIMP-/MSI-groups were equally hypomethylated for LINE-1, suggesting that microsatellite instability is the main molecular alteration associated with lack of LINE-1 hypomethylation.

Here, we document one more molecular alteration associated with this risk factor.

The HER2 gene is amplified in 15-20% of breast cancers and this molecular alteration carries with it a more aggressive clinical course [ 2- 4].

Molecular alteration associated with the unfavourable prognosis of the WDTC is genetic and epigenetic alterations of signalling pathways RAS-RAF-MEK-MAPK-ERK pathways RAS-RAF-MEK-MAPK-ERKe pathways RAS-RAF-MEK-MAPK-ERK

In order to define molecular alteration associated with obesity and fasting states in young and old obese mice, we used hepatic and muscle samples from mice at 16 and 48 weeks of age.

Survival rates achieved with conventional chemotherapy combinations have plateaued and median survival in patients with molecular alteration that can be targeted with novel drugs is only around 2 3 years [ 7– 9].