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Their overlap provides evidence that molecular aging processes in Ercc1-deficient mouse glomeruli are comparable to those in WT glomeruli.
One of the molecular pathways implicated in molecular aging relates to oxidative stress, a process incriminated in aging overall [ 44].
This concept has implications that go beyond mere aesthetics: perceived age is a robust biomarker of aging that predicts survival in certain groups of patients 2 and correlates with important functional and molecular aging phenotypes.
In this paper we develop the hypothesis that the activation of transposable elements (TEs), which inhabit the genomes of all life forms, is an important and hitherto poorly explored molecular aging process.
Earlier this year Dr. Zhang and his colleagues in San Diego reported that a kind of molecular aging clock is embedded in our genomes whose speed can be measured via blood testing.
Here, we explore the hypothesis that development of BPD involves disturbance of conserved pathways of molecular aging that may contribute to premature aging of the lung and an increased susceptibility to chronic lung diseases in adulthood.
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In bestowing its award, the Lasker Foundation noted that Dr. Kety's "visionary leadership in mental health," helped usher "psychiatry into the molecular age".
Aiming at improving the accuracy of molecular age estimation from blood, we investigated different types of biomarkers.
The molecular age of medicine has provided genomic tools that can identify a large number of potential therapeutic targets in individual patients, heralding the promise of personalized treatment.
Since blastomeres in 32-cell stage embryos and in 32/2-cell embryos are exactly at the same molecular age, this result reinforces the conclusion that cell shape plays an important role in lineage allocation.
Discordance among individual molecular age estimates, or between molecular age estimates and the fossil record, is observed in many clades across the Tree of Life.
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