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Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type: definition of molecular abnormality in transthyretin (prealbumin).
"We hope to treat the underlying molecular abnormality".
A professor of biology, Dr. Ingram was best known for his discovery, in the early 1950's, that a single amino acid substitution is responsible for the molecular abnormality that leads to sickle cell anemia.
Unlike myxomatous degeneration in Marfan syndrome, which has been reported to result from a mutation in the gene that codes for the extracellular structural protein fibrillin, no specific molecular abnormality has been documented to be the underlying cause of myxomatous degeneration in mitral valve prolapse syndrome (MVPS).
As long as researchers understand the crucial molecular abnormality in a cancer, design a drug to fix that problem, and use it in only in patients who have that molecular anomaly, then such targeted therapies can be effective.The need for combinationsIn general, the academic community and pharmaceutical companies agree with this assessment.
Bumb discovered that crushing up essentially imperfect diamonds into dust created a fluorescent, reflective light that could highlight any molecular abnormality.
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Molecular abnormalities commence in normal-appearing epithelium in chronically inflamed gallbladders.
Matching treatment to molecular abnormalities appears as a promising strategy.
Most cancers have multiple genetic alterations and molecular abnormalities.
With the advent of deep sequencing technologies, dozens of molecular abnormalities have been identified in MDS.
Molecular abnormalities have also been identified in tumors other than adenocarcinoma (squamous and small cell carcinoma).
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