Sentence examples for molecular abnormalities were from inspiring English sources
Recently several molecular abnormalities were reported to associate with sensitivity or resistance to EGFR inhibitors, including somatic mutations in the EGFR tyrosine kinase domain, EGFR gene amplification, KRAS mutation, and MET amplification [14], [15], [16], [17].
121 Subsequently, molecular abnormalities were investigated in 11 patients from nine unrelated families.
Reports of leukaemia cell cytogenetic and molecular abnormalities were obtained from the treating COG institution.
If one or several molecular abnormalities were identified, then patients were randomised.
Remarkably, additional molecular abnormalities were exclusively detected in the single CEBPA mutation group, including one patient with FLT3-ITD and one with NPM1 mutation.
These additional molecular abnormalities were at times evident long before treatment including, in one case, 17 months prior to starting targeted therapy (case #8).
Risk stratification, based on cytogenetics and molecular abnormalities, was used to categorize patients into three groups: favorable-, intermediand-, and unfavorable-risk groups [4].
The most frequent molecular abnormalities are alterations to the tumor suppressor, p53 (Ahuja et al. 1989).
The clinical impact of these different genetic and molecular abnormalities is 3-fold.
The diagnosis of refractory cytopenia in July 2010 without genetic and molecular abnormalities was followed by bone marrow transplantation (BMT).
The screening platform is an adaptable 28-gene Nextera next-generation sequencing platform designed by Illumina, covering the range of molecular abnormalities being targeted.
