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9 Less is known about the molecular abnormalities underlying the other types of thyroid cancer.
The demonstration of genetic aberrations exhibiting prognostic significance in this relatively small cohort of tumours, using a low-resolution technology, provides strong encouragement for the continued investigation of the molecular abnormalities underlying HNSCC and other tumours.
Furthermore, the assessment of RV function mainly revolves around techniques evaluating the RV structure and function such as echocardiography, Doppler, MRI and pulmonary angiography rather than investigating the cellular and the molecular abnormalities underlying the RV dysfunction in CHD.
This suggests that all ovarian high-grade serous carcinomas arise through oncogenic mechanisms that result in chromosomal instability, irrespective of BRCA status; the molecular abnormalities underlying this in the BRCA intact tumors remains unknown.
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Little is known about the molecular abnormalities that underlie these and other features described for the Tc1.
The modularity of the model signatures may reflect differences in cellular context (e.g comparing in-vitro culture to in-vivo conditions), the plethora of genomic abnormalities underlying any given tumour, and also inherent complex cross-talk between molecular pathways.
Findings thus reveal clear structural abnormalities underlying the functional abnormalities in the putative VWFA in WRD.
However, little is known about the circuit abnormalities underlying this impairment.
The genetic abnormalities underlying AML affect signal transduction pathways, transcription factors and epigenetic modifiers.
These findings provide new mechanistic links between air pollution and metabolic abnormalities underlying IR.
It is further evident that many genetic abnormalities underlying tumor progression are probably phenotypically silent.
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