Sentence examples for molecular abnormalities including from inspiring English sources

The complex process that drives the development of leukemia could rise from several clonal molecular abnormalities, including copy number gains and losses in the genome leading to activation of proto-oncogenes and silencing (or deletion) of tumor suppressor genes, respectively [3], [4].

Endometriosis shows molecular abnormalities, including the activation of the oncogenetic pathway [ 23] that allows the endometrial tissue to implant, survive, and invade the ovarian and peritoneal tissue.

The process of tumorigenesis needs to be initiated and promoted by molecular abnormalities including oncogenes activation and tumor suppressor genes (TSGs) inactivation [ 2].

Overall, our mutational annotations suggest that the pathological consequences of dysfunctional DRS could stem from various molecular abnormalities including defective dimerization, incompetent tRNA binding and structural instability.

In fact, for several actionable molecular abnormalities, including ALK rearrangements, the median age of onset may be several years younger than for the general lung cancer population (Weickhardt and Camidge, 2011).

Molecular abnormalities include JAK2 V617F [Mendelian Inheritance in Man (MIM) reference 614521], a mutation found in 50% of ET patients (Kralovics et al, 2005).

Molecular abnormalities include expression of oncogenes, such as Ki-ras, c- myc, c- erb-B-2 and bcl-2, and tumour suppressor genes, such as p53, Rb and FHIT (fragile histidine triad) in lung cancer (Otterson et al, 1998; Salgia and Skarin, 1998).

Although numerous genetic abnormalities, including MYCN amplification, are associated with tumour progression and poor outcome, the molecular mechanisms responsible for the pathogenesis of aggressive neuroblastoma remain unclear.

Molecular genetic studies of lung cancer have revealed that clinically evident lung cancers have multiple genetic and epigenetic abnormalities, including DNA sequence alterations, copy number changes, and aberrant promoter hypermethylation.

One patient had midline abnormalities, including bilateral optic nerve hypoplasia.

CMR abnormalities, including LAV.